Release-controlled curcumin proliposome produced by ultrasound-assisted supercritical antisolvent method

• Curcumin proliposomes were prepared by SAS assisted with ultrasound.
• Curcumin release could be controlled from the prepared proliposomes.
• Curcumin proliposomes are highly stable under low temperature storage.

Curcumin proliposome (CPL) was prepared using supercritical antisolvent technique assisted with ultrasound. The effects of the process parameters, such as weight ratio of starting material, pressure, temperature, and ultrasound power, on the entrapment efficiency (EE) and the drug loads were investigated. The latter three parameters were optimized using response surface methodology in terms of their effects on EE. The morphology and structure of the generated CPL were characterized by SEM, XRD and DSC. The in vitro release of the curcumin proliposome (CL) formed via hydration of the CPL was studied. The results indicated that the release of the curcumin could be controlled by manipulating the morphology of the CPL including the precipitation form of the starting materials, the particle size, and the particle fusion. The CPL was stable for at least 3 months at low temperature storage.

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