کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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230606 | 1427396 | 2013 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Experimental investigation and modeling of the solubility of carvedilol in supercritical carbon dioxide Experimental investigation and modeling of the solubility of carvedilol in supercritical carbon dioxide](/preview/png/230606.png)
Solubility of carvedilol in temperature and pressures of 308338 K and 160400 bar was measured.Static method coupled with gravimetric analysis was used to obtain the solubility of carvedilol.Solubility of carvedilol was in the range of 1.12 ÿ 105 and 5.01 ÿ 103 based on mole fraction.Solubilities correlated by four correlations namely MST, Bartle et al., Chrastil and K-J models.
This study was aimed to measure the solubility of carvedilol in the temperature and pressure ranges of 308338 K and 160 bar to 400 bar, respectively. In this direction, a homemade high pressure visual equilibrium cell was used to measure the solubility of carvedilol using a static method coupled with gravimetric technique. The results revealed that the carvedilol solubility was ranged between 1.12 ÿ 105 and 5.01 ÿ 103 based on the mole fraction (mole of carvedilol/mole of carvedilol + mole of CO2) in this study as the temperature and pressure was changed. Finally, the results were correlated using four density-based semi-empirical correlations including Chrastil, MendezSantiagoTeja (MST), Bartle et al., and Kumar and Johnston (K-J) models. Results revealed that although the K-J model leads to the lowest average absolute relative deviation percent (AARD %) of 6.27%, but it could not be considered as the most accurate correlation since all the used four correlations introduces AARD % of about 610% which may be in the same range as the experimental error.
Measured solubility of carvedilol at different pressures and different isotherms.Figure optionsDownload as PowerPoint slide
Journal: The Journal of Supercritical Fluids - Volume 81, September 2013, Pages 42–47