Analyzing the solubility of fluoxetine hydrochloride in supercritical carbon dioxide

In the pharmaceutical industry where the supercritical fluid-based technologies are utilized it is very important and vital to know the accurate value of the equilibrium solubility of solids required for the engineers to determine the size of the equipments. According to this requirement, the purpose of this study was measuring the solubility of fluoxetine hydrochloride with IUPAC name of 3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine hydrochloride using a static method coupled with gravimetric method. The measured solubility data at the temperature and pressure range of 308.15–338.15 K and 16–40 MPa was ranged between 2.65 × 10−5 and 8.12 × 10−4 based on the mole fraction. The results revealed that the solubility was increased when the pressure was increased while the effect of the temperature was more complex. Finally, the measured solubility data were correlated using three different correlations namely Bartle et al., Mendez-Santiago–Teja and Kumar and Johnston. The results of modeling revealed that the Bartle et al. model leads to the lowest average absolute relative deviation (AARD %) of 9.48.

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► Fluoxetine hydrochloride solubility in ranges of 308.15–338.15 K and 16–40 MPa was measured.
► Fluoxetine hydrochloride solubility (mole fraction) was between 2.65 × 10−5 and 8.12 × 10−4.
► Solubilities were correlated using Bartle, Mendez-Santiago–Teja and Kumar and Johnston.
► Results revealed both good correlative and extrapolative capability of the used models.