Solubility of gabapentin in supercritical carbon dioxide

The purpose of this study was to measure the solubility of gabapentin in supercritical carbon dioxide at different pressures and temperatures of 16–40 MPa and 308–338 K, respectively. The measured solubility data revealed that solubility of gabapentin was 8.97 × 10−5–7.36 × 10−3 based on the mole fraction in supercritical carbon dioxide at the aforementioned operational conditions. At last, the obtained results were correlated using four density based semi-empirical correlations namely Bartle et al., Mendez-Santiago and Teja (MST), Chrastil and Kumar and Johnston (K–J). The results revealed that according to the obtained average absolute relative deviations (AARD) for the used density based correlations of MST (AARD % = 9.88%), Chrastil (AARD % = 9.47%), K–J (AARD % = 11.5%) and Bartle et al. (AARD % = 9.29%), none of the correlations can be considered as the most accurate one. In other words, all the examined semi-empirical correlations are in the same level of accuracy.

Figure optionsDownload as PowerPoint slideHighlights
► Gabapentin solubility in ranges of 308–338 K and 16–40 MPa was measured.
► Gabapentin solubility was between 8.97 × 10−5–7.36 × 10−3 based on the mole fraction.
► Solubilities were correlated using Bartle, Mendez-Santiago–Teja and Kumar and Johnston.
► Results revealed both good correlative and extrapolative capability of the used models.