Solubility of ketoprofen in supercritical carbon dioxide

In the present study, solubility of ketoprofen in the supercritical carbon dioxide was measured experimentally using gravimetric method. In this direction the temperature and pressure was ranged between 308.15–338.15 K and 160–400 bar, respectively. The obtained solubilites revealed that the ketoprofen solubility was in the range of 2.21 × 10−5 to 7.12 × 10−4 mole fraction according to the different temperatures and pressures. Measured solubilites demonstrated that pressure and temperature have a direct effect on the solubility enhancement. Finally, the least square method and curve fitting approaches were utilized to find the fitting parameters of four semi-empirical density based correlations including Mendez-Santiago–Teja, Bartle, Chrastile and Kumar and Johnston methods. The results revealed that Bartle et al. method was able to correlate the ketoprofen solubility with a minimum average absolute relative deviation (AARD %) of 5.95%.

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► Ketoprofen solubility was measured in a wide range of temperature and pressure.
► Ketoprofen solubility was in the range of 2.21 × 10−5 to 7.12 × 10−4 mole fraction.
► No crossover pressure was obtained for ketoprofen in this study.
► Solubilites were correlated via MST, Bartle, Chrastile and K–J empirical correlations.