کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
232391 1427480 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Formation and stabilization of ibuprofen nanoparticles in supercritical fluid processing
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Formation and stabilization of ibuprofen nanoparticles in supercritical fluid processing
چکیده انگلیسی

Rapid expansion of a supercritical solution into a liquid solvent (RESOLV) was applied to the nanosizing of ibuprofen particles in aqueous suspension. When the rapid expansion was into neat water, the initially formed nanoscale ibuprofen particles agglomerated into large aggregates. Various water-soluble polymers of different molecular weights were added to the aqueous receiving medium in RESOLV as stabilization agent for the produced nanoparticle suspension, and their effects on the properties of the harvested ibuprofen nanoparticles were evaluated. A conclusion is that the selection of stabilization agent in RESOLV may also be used to alter the sizes and morphology of the nanosized drug particles.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Supercritical Fluids - Volume 37, Issue 3, May 2006, Pages 279–286
نویسندگان
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