Systemic canine histoplasmosis: A case report from Ecuador

• Increasing information about H. capsulatum epidemiology.
• Canine histoplasmosis with initial mild respiratory and digestive symptoms.
• Skin and gingival lesions in canine systemic histoplasmosis.

Histoplasmosis is a zoonotic systemic mycosis caused by Histoplasma capsulatum. We report a case of a female canine, 4 years old, presenting multifocal lymphadenitis and skin and gingival lesions, in Ecuador. Based on cytological, histopathological, histochemical analyses, fungal culture and DNA sequencing of the ITS region of the fungus, the diagnosis confirmed the presence of H. capsulatum as the agent of infection. The treatment plan included ketoconazole with a satisfactory outcome.