Disseminated Scedosporium prolificans infection in a Labrador retriever with immune mediated haemolytic anaemia

• Disseminated scedosporiosis due to Scedosporium prolificans is described in a dog.
• Chronic prednisolone and cyclosporine therapy preceded disseminated scedosporiosis.
• Combination therapy with oral voriconazole and terbinafine was prescribed.
• Despite an initial response progressive disease occurred.

Disseminated scedosporiosis is rare in dogs and is usually reported in German Shepherds with suspected heritable immunodeficiency. This is the first report of disseminated scedosporiosis due to Scedosporium prolificans in a Labrador retriever dog that was receiving immunosuppressive drug therapy for treatment of immune-mediated haemolytic anaemia. Despite cessation of immunosuppressive medications and an initial response to aggressive treatment with voriconazole and terbinafine the dog developed progressive disease with neurological signs necessitating euthanasia six months from diagnosis.