کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2401464 1102343 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Unusual spinal tuberculosis in an Avar Age skeleton (Csongrád-Felgyő, Ürmös-tanya, Hungary): A morphological and biomolecular study
ترجمه فارسی عنوان
سل ستون فقرات غیرطبیعی در یک اسکلت سن آور (کسنگرد-Felgyő، Ürmös-تانیا، مجارستان): مطالعه مورفولوژیکی و بیومولکولی
کلمات کلیدی
دیری‌نآسیب‌شناسی؛ سل نخاعی؛ ضایعات لیتیک چندگانه؛ تغییرات Endocranial؛ مطالعه بیومولکولار؛ مایکوباکتریوم توبرکلوزیس
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی

SummaryThe paleopathological analysis of a well-preserved young adult female skeleton from the AD 7–8th century (Avar Age) in Hungary revealed multiple lytic lesions in all of the thoracic and lumbar vertebral bodies. The lesions were characterized by smooth marginal zones and space-occupying mass appearance. The considerable loss of spongy bone in the thoracolumbar vertebrae resulted in angular deformity and fusion, characteristic of the healing stage of TB. Osteolytic lesions were also observed on the vertebral processes, ribs and sternum. On the endocranial surface, abnormal blood vessel impressions were revealed, indicating some kind of meningitis.The X-ray and CT analysis of the affected bones detected abnormal structures and cystic zones of destruction. The lesions were however not always bordered by areas of increased density, which is typical in cystic TB. Vertebral remains were also subjected to biomolecular analysis in two different laboratories, which attested the presence of Mycobacterium tuberculosis complex (MTBC) DNA and supported the paleopathological diagnosis of TB. Spoligotyping analysis confirmed the presence of MTBC DNA and more specifically an infection caused by bacteria belonging to the M. tuberculosis lineage.This case study provides new data for the paleoepidemiology of TB in this geographical area and historical period, and draws attention to the great variability of TB lesions in the human skeleton.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tuberculosis - Volume 95, Supplement 1, June 2015, Pages S29–S34
نویسندگان
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