کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2401572 1102348 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mycobacterium tuberculosis – Heterogeneity revealed through whole genome sequencing
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Mycobacterium tuberculosis – Heterogeneity revealed through whole genome sequencing
چکیده انگلیسی

SummaryThe emergence of whole genome sequencing (WGS) technologies as primary research tools has allowed for the detection of genetic diversity in Mycobacterium tuberculosis (Mtb) with unprecedented resolution. WGS has been used to address a broad range of topics, including the dynamics of evolution, transmission and treatment. Here, we have analyzed 55 publically available genomes to reconstruct the phylogeny of Mtb, and we have addressed complications that arise during the analysis of publically available WGS data. Additionally, we have reviewed the application of WGS to the study of Mtb and discuss those areas still to be addressed, moving from global (phylogeography), to local (transmission chains and circulating strain diversity), to the single patient (clonal heterogeneity) and to the bacterium itself (evolutionary studies). Finally, we discuss the current WGS approaches, their strengths and limitations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tuberculosis - Volume 92, Issue 3, May 2012, Pages 194–201
نویسندگان
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