کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2401577 1102348 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dynamic and complex Mycobacterium tuberculosis microevolution unrevealed by standard genotyping
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Dynamic and complex Mycobacterium tuberculosis microevolution unrevealed by standard genotyping
چکیده انگلیسی

SummaryWe performed an in-depth analysis of a large Mycobacterium tuberculosis cluster involving nine isolates with identical or highly similar RFLP types. The strain involved in this transmission cluster microevolved and accumulated up to five differential IS6110 transposition events, several of them not revealed by standard genotyping approaches. Some of these events probably generated extended deletions. In two cases of tuberculosis within the cluster, we observed the simultaneous presence of both the reference and microevolved variants. A longitudinal genotypical survey of M. tuberculosis in a real clinical evolutionary scenario can reveal dynamic and complex microevolution events.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tuberculosis - Volume 92, Issue 3, May 2012, Pages 232–235
نویسندگان
, , , ,