Pyrazinamide

Generic and additional names: Pyrazinamide; pyrazinoic acid amide; pyrazine carboxylamideCAS name: PyrazinecarboxamideCAS registry #: 98-96-4Molecular formula: C5H5N3OMolecular weight: 123.11Intellectual property rights: Generic, first synthesized in 1936Brand names: Pezetamid (Hefa-Frenon); Pyrafat (Fatol); Pirilène (Cassenne); Piraldina (Bracco); Tebrazid (Searle); Unipyranamide (Unichem); Zinamide (Merck & Co.)Derivatives: Morphazinamide; pyrazinamide Mannich bases also active1Solubility: Soluble in chloroform, methylene chloride; less soluble in benzene; sparingly soluble in water[Merck Index]Polarity: Log P −1.884 [DrugBank]Melting point: 192ºC [DrugBank]Formulation and optimal human dosage: 500 mg tablets available.Dose 20–25 mg/kg daily, or 50–70 mg/kg three times a week. Pyrazinamide is also available as part of fixed-dose combinations with other TB drugs such as isoniazid and rifampicin (Rifater® is an example).Figure optionsDownload high-quality image (6 K)Download as PowerPoint slide