کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2402051 1102391 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The genetic portrait of an outbreak strain
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
The genetic portrait of an outbreak strain
چکیده انگلیسی

SummaryUnique events in the genome of Mycobacterium tuberculosis, including deletions and IS6110 insertions, have been proposed to be responsible for the virulence phenotype of outbreak strains. Based on this premise, we determined ten IS6110 insertion sites in the genome of the M. tuberculosis CH strain, which was responsible for a large outbreak in Leicestershire, England. Together with previous data on genomic deletions, it was found that 16 genes were mutated either by IS6110 insertions or deletions. The likely impact of these genomic events on the phenotype of the CH strain is discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tuberculosis - Volume 86, Issue 5, September 2006, Pages 357–362
نویسندگان
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