کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2428259 | 1106293 | 2012 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Characterization of immune modulating functions of γδ T cell subsets in a gnotobiotic pig model of human rotavirus infection Characterization of immune modulating functions of γδ T cell subsets in a gnotobiotic pig model of human rotavirus infection](/preview/png/2428259.png)
We characterized immune modulating functions of porcine γδ T cell subsets in rotavirus infection using a gnotobiotic pig model of human rotavirus infection and sort-purified lymphocyte autologous co-cultures. We demonstrated that CD2+CD8− and CD2−CD8− γδ T cells have mainly pro-inflammatory function as evident by directly secreting IFN-γ or promoting CD4+ αβ T cell proliferation and IFN-γ production, whereas CD2+CD8+ γδ T cells mainly exert regulatory T cell function by expressing FoxP3, secreting IL-10 and TGF-β or increasing IL-10 and TGF-β production by CD4+ αβ T cells. γδ T cells responded to rotavirus infection by increasing TLR2, TLR3, TLR9 expression and IFN-γ and/or TGF-β production. The CD8− subsets likely differentiate into CD8+ subset by acquiring CD8 expression, explaining in part the apparently dual functions of CD2+CD8+ and CD2+CD8− subsets. Thus, both CD8+ and CD8− γδ T cell subsets can contribute to anti-rotavirus immunity and to the maintenance and restoration of intestinal and systemic homeostasis.
Journal: Comparative Immunology, Microbiology and Infectious Diseases - Volume 35, Issue 4, July 2012, Pages 289–301