کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2428290 | 1106296 | 2013 | 10 صفحه PDF | دانلود رایگان |
Culex flavivirus (CxFV), a member of the genus flavivirus, is a novel insect-specific flaviviruses that can be divided into two subtypes, the cytopathic Asia/U.S. and the noncytopathic Africa/Caribbean/Latin American subtypes. The CxFV circulates in several Asian countries, and here we conducted the first study investigating CxFV in Taiwan. A total of 14,016 mosquitoes were collected between 2010 and 2012 and 3.4% (6/179) of the pools were CxFV-positive. The phylogenetic analyses indicate that the Taiwan isolates are closely related to the Africa/Caribbean/Latin American subtype, but form an independent cluster. In the cytology experiments, the CxFV Taiwan isolate infected only mosquito cells and caused cell–cell fusion that might be associated with a unique glycine residue at position 117 within the envelope protein, which is shared with the cytopathic effect-causing Asia/US subtype. This study marks the first time the Africa/Caribbean/Latin American subtype of CxFV has been identified in an Asian country and grouped into a novel cluster.
Journal: Comparative Immunology, Microbiology and Infectious Diseases - Volume 36, Issue 4, July 2013, Pages 387–396