کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2428352 | 1106306 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification of two paralogous caprine CD36 genes that display highly divergent mRNA expression profiles
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Identification of two paralogous caprine CD36 genes that display highly divergent mRNA expression profiles Identification of two paralogous caprine CD36 genes that display highly divergent mRNA expression profiles](/preview/png/2428352.png)
چکیده انگلیسی
The CD36 molecule plays a pivotal role in a variety of immunological and cellular processes, including pathogen recognition, inflammation and apoptosis. Herein, we demonstrate that this gene is duplicated in goats, with two copies (CD36 and CD36-like) that display highly divergent mRNA expression profiles. In this way, CD36 mRNA is mostly expressed in the adipose tissue and heart whilst CD36-like mRNA shows a high expression in the liver. We have also found evidence of the presence of two paralogous CD36 and CD36-like genes in the bovine genome, suggesting that CD36 duplication took place before goat-cattle radiation, i.e. at least 20 MYR ago. Finally, we have characterized the polymorphism of the coding regions of the goat CD36 and CD36-like genes. In doing so, we have identified one synonymous polymorphism at the CD36-like gene (c.390A>C) that displays a significant association (PÂ =Â 0.04) with milk somatic cell count, a parameter often used to diagnose mastitis in domestic ruminants.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Immunology, Microbiology and Infectious Diseases - Volume 36, Issue 1, January 2013, Pages 1-7
Journal: Comparative Immunology, Microbiology and Infectious Diseases - Volume 36, Issue 1, January 2013, Pages 1-7
نویسندگان
A. Zidi, A. Castelló, J. Jordana, J. Carrizosa, B. Urrutia, J.M. Serradilla, M. Amills,