کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2428953 1106463 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Kinetics of lymphocyte subpopulations in allogeneic grafted scales of ginbuna crucian carp
ترجمه فارسی عنوان
سینتیک جمعیت زیر کشت لنفوسیت ها در مقیاس آلبومین جلبنای کوهی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی


• Rejection of allogeneic scale grafts occurred 3 days after transplantation.
• CD4+ T cells were detected as early as 3 days after transplantation.
• CD8α+ T cell counts were highest at 3 days post-transplantation and they accumulated on the border of the grafted scales.
• Both CD4+ and CD8α+ T cells may play major roles in allogeneic rejection.
• Other cell types such as sIgM+ cells or phagocytic cells also may contribute to allograft rejection.

In mammals the rejection of allografts is primarily accomplished by cell-mediated immunity including T cells. Recently, considerable studies reveal the existence of helper and cytotoxic T cell subsets in fish. Here we investigate the kinetics of CD4+ and CD8α+ T cells along with sIgM+ cells and phagocytic cells in an allogeneic scale graft model using ginbuna crucian carp for understanding the mechanisms of cell-mediated immune response. The results showed that CD4+ T cells first infiltrated into allogeneic scales followed by CD8α+ and sIgM+ cells, and finally phagocytic cells appeared in the graft. Furthermore, most of the CD8α+ T cells appeared on the border of the allografted scales at the time of rejection. These results suggest that T cells play crucial roles and work together with other cell types for completion of allograft rejection.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 52, Issue 1, September 2015, Pages 75–80
نویسندگان
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