کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2429184 1106482 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transcriptional response of immune genes in gills and the interbranchial lymphoid tissue of Atlantic salmon challenged with infectious salmon anaemia virus
ترجمه فارسی عنوان
پاسخ ترانسپورتی از ژن های ایمنی در گیلان و بافت لنفوئیدی بین نژاد آتلانتیک، به چالش کشیده شده با ویروس آنمی ویروس عفونی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی


• No detection of infectious salmon anaemia virus in the interbranchial lymphoid tissue.
• Early replication of infectious salmon anaemia virus in gills.
• Strong systemic response in all examined tissues.

Previously, it has been assumed that fish lack organized mucosa-associated lymphoid structures. Recently, an interbranchial lymphoid tissue (ILT) was described in salmonid gills at a site with substantial exposure to antigen.In this study, immune responses were examined in gills, mid-kidney and the laser-dissected ILT of Atlantic salmon (Salmo salar L.) infected with infectious salmon anaemia virus (ISAV).A strong innate response was observed in gills and mid-kidney and even in the laser-dissected ILT, despite the fact that no virus could be traced in this tissue. A small delayed increase in IgT transcripts, exclusively in the ILT, could indicate that this tissue has a role as a secondary lymphoid organ with clonal expansion of IgT expressing B-cells. Compared to the other examined tissues, gills displayed the earliest replication of the virus, further supporting this tissue as the main entry route for infection with ISAV.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 45, Issue 1, July 2014, Pages 107–114
نویسندگان
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