کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2429430 | 1553580 | 2013 | 24 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Advances in research of fish immune-relevant genes: A comparative overview of innate and adaptive immunity in teleosts Advances in research of fish immune-relevant genes: A comparative overview of innate and adaptive immunity in teleosts](/preview/png/2429430.png)
Fish is considered to be an important model in comparative immunology studies because it is a representative population of lower vertebrates serving as an essential link to early vertebrate evolution. Fish immune-relevant genes have received considerable attention due to its role in improving understanding of both fish immunology and the evolution of immune systems. In this review, we discuss the current understanding of teleost immune-relevant genes for both innate and adaptive immunity, including pattern recognition receptors, antimicrobial peptides, complement molecules, lectins, interferons and signaling factors, inflammatory cytokines, chemokines, adaptive immunity relevant cytokines and negative regulators, major histocompatibility complexes, immunoglobulins, and costimulatory molecules. The implications of these factors on the evolutionary history of immune systems were discussed and a perspective outline of innate and adaptive immunity of teleost fish was described. This review may provide clues on the evolution of the essential defense system in vertebrates.
► We summarize the major advances regarding key factors involved in fish immunology.
► We provide a perspective outline of innate and adaptive immunity of teleost fish.
► We show the status of fish immunity throughout vertebrates from a comparative angle.
Journal: Developmental & Comparative Immunology - Volume 39, Issues 1–2, January–February 2013, Pages 39–62