کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2429604 1106508 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Kinetics of the avian influenza-specific humoral responses in lung are indicative of local antibody production
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Kinetics of the avian influenza-specific humoral responses in lung are indicative of local antibody production
چکیده انگلیسی

The role and kinetics of respiratory immunoglobulins in AIV infection has not been investigated. In this study we determined the numbers of both total antibody secreting cells (ASC) and virus-specific ASC in lung, spleen, blood and bone marrow (BM) following low-pathogenic AIV infection. Antiviral humoral immune responses were induced both locally in the lung and systemically in the spleen. Responses in the lung and BM preceded responses in the spleen and in blood, with virus-specific IgY ASC already detected in lung and BM from 1 week post-primary inoculation, indicating that respiratory immune responses are not induced in the spleen, but locally in the lung. ASC present in the blood of the lungs and co-isolated during lymphocyte isolation from the lungs have no major impact on the ASC detected in the lungs based on statistical correlation.


► Chickens were infected with low-pathogenic AIV.
► Numbers of antibody secreting cells were determined in lung, spleen, blood and BM.
► Antiviral humoral responses were induced locally in the lung and systemically in the spleen.
► Responses in the lung and bone marrow preceded responses in the spleen and in blood.
► This indicates that respiratory immune responses are induced locally in the lung.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 36, Issue 2, February 2012, Pages 317–322
نویسندگان
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