کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2430177 1106549 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A TLR9 homolog that is up-regulated by IFN-γ in Atlantic salmon (Salmo salar)
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
A TLR9 homolog that is up-regulated by IFN-γ in Atlantic salmon (Salmo salar)
چکیده انگلیسی

SummaryMembers of the Toll-like receptor family 9 (TLR9) subfamily sense viral and bacterial DNA present in the endosomal compartment. Here we describe the cloning and regulation of a TLR9 gene from Atlantic salmon (Salmo salar). The salmon TLR9 cDNA encodes 1075 amino acids and analysis of the inferred protein sequence shows that several amino acid residues known to be important for the functions of TLR9 in mammals are conserved in salmon. Furthermore, TLR9 expression was elevated in head kidney leukocytes after in vitro treatment with CpG ODNs and recombinant trout interferon (IFN)-γ. IFN-γ was the strongest inducer of TLR9 expression. Together, the results indicate that the structure, the expression and possibly the function of TLR9 are conserved across the teleost and mammalian lineages.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 32, Issue 6, 2008, Pages 603–607
نویسندگان
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