کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2430436 1553583 2006 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
B cell and antibody repertoire development in rabbits: The requirement of gut-associated lymphoid tissues
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
B cell and antibody repertoire development in rabbits: The requirement of gut-associated lymphoid tissues
چکیده انگلیسی

The antibody repertoire of rabbits has interested immunologists for decades, in part because of the ease with which large quantities of high affinity antibodies can be obtained in serum, and in part because of the presence of genetic variants, allotypes, within VH, CH and CL regions. Studies of these allotypes led to the initial descriptions of allelic exclusion, and neonatal suppression of serum Ig production (allotype suppression), and were instrumental in demonstrating that V and C regions are encoded by separate genes and are usually expressed in cis. The immune system of rabbit continues to be of interest primarily because of the use of both gene conversion and somatic hypermutation to diversify rearranged heavy and light chain genes and the role that gut-associated lymphoid tissues (GALT) and intestinal flora play in developing the primary (preimmune) antibody repertoire.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 30, Issues 1–2, 2006, Pages 137–153
نویسندگان
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