کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2431032 | 1106741 | 2015 | 5 صفحه PDF | دانلود رایگان |
• The tryptophol was identified as a metabolite which was involved in bacteriophage–thermophile interactions.
• The dietary addition of tryptophol reduced the mortality of shrimp.
• The WSSV copies in shrimp were significantly decreased when supplemented with the tryptophol.
White spot syndrome virus (WSSV) is a shrimp pathogen responsible for significant economic loss in commercial shrimp farms and until now, there has been no effective approach to control this disease. In this study, tryptophol (indole-3-ethanol) was identified as a metabolite involved in bacteriophage–thermophile interactions. The dietary addition of tryptophol reduced the mortality in shrimp Marsupenaeus japonicus when orally challenged with WSSV. Our results revealed that 50 mg/kg tryptophol has a better protective effect in shrimp than 10 or 100 mg/kg tryptophol. WSSV copies in shrimp were reduced significantly (P < 0.01) when supplemented with 50 mg/kg tryptophol, indicating that virus replication was inhibited by tryptophol. Consequently, tryptophol represents an effective antiviral dietary supplement for shrimp, and thus holds significant promise as a novel and efficient therapeutic approach to control WSSV in shrimp aquaculture.
Inhibition of WSSV replication in shrimp by dietary supplementation of 50 mg/kg tryptophol. WSSV copies in shrimp were reduced significantly (P < 0.01) when supplemented with 50 mg/kg tryptophol, indicating that virus replication was inhibited by tryptophol.Figure optionsDownload as PowerPoint slide
Journal: Fish & Shellfish Immunology - Volume 47, Issue 2, December 2015, Pages 777–781