Non-lethal heat shock induces HSP70 and HMGB1 protein production sequentially to protect Artemia franciscana against Vibrio campbellii

• HSP70 and HMGB1 proteins are molecular chaperones for protein and DNA, respectively.
• In presence of stressors, these proteins are involved in generating immune responses.
• HSP70 and HMGB1 were elevated sequentially in Artemia in response to mild heat stress.
• These alterations were associated with improved survival of Vibrio-challenged Artemia.