Studies of macrophage cellular response to the extracellular hydrogen peroxide by tilapia model

• The effect of extracellular hydrogen peroxide on the macrophage migration.
• The effect of extracellular hydrogen peroxide on the phagocytosis of macrophage.
• The effect of extracellular hydrogen peroxide on the cellular physiology response.
• Role of extracellular hydrogen peroxide on macrophage.

Reactive oxygen species (ROS) may act as signaling molecules in the physiology responses and the present study aims to investigate the effect of extracellular hydrogen peroxide on macrophages cellular response. The results obtained in the present study showed that the extracellular hydrogen peroxide affectively alter the membrane potential of the cell membrane and ion exchange channels in the cell membrane through intracellular NAD turnover that may lead to an intracellular calcium ion concentration alteration and subsequently induce the downstream signal activation.