کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2432646 1106801 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nodavirus encephalopathy in turbot (Scophthalmus maximus): Inflammation, nitric oxide production and effect of anti-inflammatory compounds
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم آبزیان
پیش نمایش صفحه اول مقاله
Nodavirus encephalopathy in turbot (Scophthalmus maximus): Inflammation, nitric oxide production and effect of anti-inflammatory compounds
چکیده انگلیسی

Nodaviruses are the etiological agents of one of the most serious viral diseases affecting marine fish aquaculture. Nodavirus infection produces an abnormal swimming behaviour and causes encephalopathy and retinopathy associated to important mortalities. The expression of TNF-α, IRF-1 and Mx was increased in turbot after nodavirus infection. A significant increase in the production of nitrogen radicals was also observed in experimentally infected turbot. Several anti-inflammatory compounds (the antioxidant N-acetylcysteine, cortisone, dexamethasone, prednisolone and aminoguanidine) were assayed to determine the role of inflammation on nodavirus infection. Cortisone and aminoguanidine were able to accelerate the mortality onset associated to nodavirus infection, modulating the gene expression of TNF-α and, in addition, modifying the arrival time of nodavirus to the brain. These results suggest the importance of early inflammatory processes to overcome the infection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fish & Shellfish Immunology - Volume 28, Issue 2, February 2010, Pages 281–288
نویسندگان
, , ,