کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2438100 | 1107703 | 2010 | 8 صفحه PDF | دانلود رایگان |

SummaryThe expression of sigma-2 receptors was investigated in nine urothelial tumours of the urinary bladder of cattle. Each tumour was associated with the presence of DNA of bovine papillomavirus type-2 (BPV-2) and expression of the E5 viral oncoprotein. Five tumours were classified as low-grade carcinoma on the basis of morphological criteria and calculation of mean nuclear area (MNA) and mean nuclear perimeter (MNP). Four tumours were classified as high-grade carcinoma. Sigma-2 receptors were overexpressed in both types of carcinoma. In control normal bovine bladder tissue the density of receptors (expressed as the Bmax) was 0.37 pmol/mg of protein. Low-grade carcinomas had a mean Bmax of 1.37 ± 0.32 pmol/mg of protein (range 1.03–1.86) and in high-grade carcinomas the mean Bmax was 10.9 ± 2.8 pmol/mg of protein (range 8.2–14). The difference in Bmax between low- and high-grade carcinomas was statistically significant (P = 0.0001).
Journal: Journal of Comparative Pathology - Volume 142, Issue 1, January 2010, Pages 19–26