کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2438652 | 1553776 | 2008 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Cellular Phenotypes in the Abomasal Mucosa and Abomasal Lymph Nodes of Goats Infected with Haemonchus contortus Cellular Phenotypes in the Abomasal Mucosa and Abomasal Lymph Nodes of Goats Infected with Haemonchus contortus](/preview/png/2438652.png)
SummaryThe distribution of T-cell subsets (CD2, CD4, CD8, and γδ) and B cells (IgM) was examined at 3, 6, 10 and 13 days post-infection (dpi) in the abomasal mucosa and abomasal lymph nodes of goats primarily infected with Haemonchus contortus. In the abomasal mucosa a mild (3 and 6 dpi) or marked (10 and 13 dpi) increase of T cells, particularly CD4+ and γδ+ lymphocytes, was observed, whereas the increase in CD8+ cells was less pronounced. B cells and IgG+ plasma cells also showed a marked increase in the abomasal mucosa at 10 and 13 dpi. The abomasal lymph nodes showed an increase in size, particularly at 10 and 13 dpi, and a decrease in the proportion of T cells, particularly CD8+ lymphocytes, due to the increased proportion of B cells. The proportion of CD4+ and γδ+ lymphocytes did not change significantly during the infection in the abomasal lymph nodes, but their absolute numbers were augmented as a result of the enlargement of the nodes. The results revealed a strong cellular and humoral immune response during the early post-infection stages. However, as indicated by the worm burdens, this rapid host response was unable to induce larval expulsion.
Journal: Journal of Comparative Pathology - Volume 138, Issues 2–3, February–April 2008, Pages 102–107