کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2438659 1553776 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuropathological Findings in a Staffordshire Bull Terrier with l-2-Hydroxyglutaric Aciduria
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Neuropathological Findings in a Staffordshire Bull Terrier with l-2-Hydroxyglutaric Aciduria
چکیده انگلیسی

Summaryl-2-Hydroxyglutaric aciduria (l-2-HGA) is a hereditary neurometabolic disorder reported in human beings and dogs. An 11-month-old Staffordshire bull terrier was suspected to have the disease, on the basis of clinical signs and magnetic resonance imaging findings. l-2-HGA was confirmed by urinary organic analysis and DNA testing and the dog was humanely destroyed. Post-mortem findings consisted only of microscopical lesions in the brain, characterized by marked spongiform changes and predominantly affecting the grey matter of the cerebral cortex, thalamus, cerebellum and brainstem. The spongiform changes were characterized by well-demarcated, clear vacuoles located at perineuronal and perivascular sites. Immunohistochemical and ultrastructural examination confirmed that the affected cells were astrocytes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Comparative Pathology - Volume 138, Issues 2–3, February–April 2008, Pages 160–164
نویسندگان
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