کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2438727 | 1107740 | 2007 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Experimental Nipah Virus Infection in Pteropid Bats (Pteropus poliocephalus) Experimental Nipah Virus Infection in Pteropid Bats (Pteropus poliocephalus)](/preview/png/2438727.png)
SummarySeventeen grey-headed fruit bats (Pteropus poliocephalus) were inoculated subcutaneously with an isolate of Nipah virus derived from a fatally infected human. A control group of eight guinea-pigs was inoculated intraperitoneally with the same isolate in order to confirm virulence. Three of eight infected guinea-pigs developed clinical signs 7–9 days post-inoculation. Infected fruit bats developed a subclinical infection characterized by the transient presence of virus within selected viscera, episodic viral excretion and seroconversion. A range of histopathological changes was observed within the tissues of infected bats. Nipah virus was excreted in bat urine while neutralizing antibody was present in serum. This intermittent, low-level excretion of Nipah virus in the urine of bats may be sufficient to sustain the net reproductive value of the virus in a species where there is regular urine contamination of the fur, mutual grooming, and where urine droplets are a feature of the environment.
Journal: Journal of Comparative Pathology - Volume 136, Issue 4, May 2007, Pages 266–272