کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2452467 1110006 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A field investigation into a suspected outbreak of pyrrolizidine alkaloid toxicosis in horses in western Queensland
ترجمه فارسی عنوان
تحقیقات میدانی در مورد شیوع مظنون به سم زدایی آلکالوئیدهای پریرولیزیدین در اسب ها در کوینزلند غربی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی


• Clinical, pathological and epidemiological findings indicated PA toxicosis.
• A likely cause was Crotalaria medicaginea plus management factors.
• The suspected exposure period coincided with a rare and localised weather pattern.
• High physiological demand for protein and denuded pasture were risk factors.
• Supplementing the horse's pasture based diet was sparing.

A disease outbreak investigation was conducted in western Queensland to investigate a rare suspected outbreak of pyrrolizidine alkaloid (PA) toxicosis in horses. Thirty five of 132 horses depastured on five properties on the Mitchell grass plains of western Queensland died in the first six months of 2010. Clinical–pathological findings were consistent with PA toxicosis. A local variety of Crotalaria medicaginea was the only hepatotoxic plant found growing on affected properties. Pathology reports and departure and arrival dates of two brood mares provided evidence of a pre wet season exposure period. All five affected properties experienced a very dry spring and early summer preceded by a large summer wet season. The outbreak was characterised as a point epidemic with a sudden peak of deaths in March followed by mortalities steadily declining until the end of June. The estimated morbidity (serum IGG > 50 IU/L) rate was 76%. Average crude mortality was 27% but higher in young horses (67%) and brood mares (44%). Logistic regression analysis showed that young horses and brood mares and those grazing denuded pastures in December were most strongly associated with dying whereas those fed hay and/or grain based supplements were less likely to die. This is the first detailed study of an outbreak of PA toxicosis in central western Queensland and the first to provide evidence that environmental determinants were associated with mortality, that the critical exposure period was towards the end of the dry season, that supplementary feeding is protective and that denuded pastures and the horses physiological protein requirement are risk factors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Preventive Veterinary Medicine - Volume 118, Issue 4, 1 March 2015, Pages 378–386
نویسندگان
, ,