کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2454736 | 1554313 | 2015 | 8 صفحه PDF | دانلود رایگان |
• Optimum organic selenium dose for enhancing gut health was determined in poultry.
• Selenium-fed broiler chickens showed reduced serum Clostridium toxins after NE infection.
• Dietary selenium enhanced serum antibody levels to Clostridium toxins.
• Dose-dependent effect of selenium on intestinal cytokine response was shown.
• Feeding organic selenium enhanced intestinal beta-defensins expression.
The effects of dietary supplementation of young broiler chickens with an organic selenium (Se) formulation, B-Traxim Se, on experimental necrotic enteritis (NE) were studied. Chickens treated with three Se doses (0.25, 0.50, 1.00 mg/kg) from hatch were orally challenged with Eimeria maxima at 14 days of age followed by Clostridium perfringens to induce NE. Chickens fed with 0.50 mg/kg Se showed significantly increased body weights and antibody levels against NetB, and significantly reduced gut lesions compared with non-supplemented chickens. However, there were no significant differences in Eimeria oocyst shedding between the Se-treated and non-supplemented groups. Levels of IL-1β, IL-6, IL-8, iNOS, LITAF, TNFSF15, AvBD6, AvBD8, and AvBD13 transcripts were increased in the gut and spleen of at least one of the three Se-treated groups compared with the non-treated group. These results suggest that dietary supplementation of young broilers with Se might be beneficial to reduce the negative consequence of NE.
Journal: Research in Veterinary Science - Volume 98, February 2015, Pages 66–73