کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2454942 1110498 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serum vascular endothelial growth factor in dogs with haemangiosarcoma and haematoma
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Serum vascular endothelial growth factor in dogs with haemangiosarcoma and haematoma
چکیده انگلیسی


• VEGF is a fundamental regulator of angiogenesis.
• Dogs with splenic masses showed higher VEGF levels compared with healthy dogs.
• Haemangiosarcomas and haematomas could not be distinguished on the basis of serum VEGF.

Splenic haemangiosarcomas are frequently seen in dogs. Because of their bad prognosis differentiation from other benign splenic lesions are of prognostic importance.However, because haemangiosarcoma is a tumour of the vascular system, it was hypothesised that vascular endothelial growth factor (VEGF) might play a major role in tumour growth and might thus be increased in the blood of affected dogs.The aim of this study was to investigate the clinical relevance of differences in serum VEGF concentrations between dogs with splenic haemangiosarcomas and those with non-malignant splenic lesions (haematomas) and healthy subjects using a canine ELISA.Serum VEGF levels were significantly higher in dogs with splenic masses compared with healthy dogs, but did not differ significantly between dogs with haemangiosarcomas and haematomas.VEGF has a potential clinical utility as a diagnostic marker for dogs with splenic lesions but may not be useful to differentiate among the various splenic lesions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Veterinary Science - Volume 97, Issue 2, October 2014, Pages 257–262
نویسندگان
, , ,