کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2454943 | 1110498 | 2014 | 8 صفحه PDF | دانلود رایگان |
• Holy Birman cats (HB) seem to be predisposed to feline infectious peritonitis (FIP).
• In this study, indicators of innate and specific immunity were assessed in HB cats.
• CD4/CD8, IFN-γ, IL12/IL4 were higher and IL-4 was lower in HB than in other breeds.
• The rate of shedders, but not of seropositivity, was lower in HB than in other cats.
• Th1 immunity seems to be stronger in HB. This may reduce the rate of shedders.
The aim of this study was to assess whether Holy Birman cats (HB) have a peculiar immune profile and a higher rate of infection by feline coronaviruses (FCoV). Leucocyte and lymphocyte subsets, antibody titers, α1-acid glycoprotein (AGP), globulin fractions, IL-4, IL-12 and IFN-γ in blood and fecal FCoV excretion were determined in HB (n = 75) and in cats from other breeds (n = 94). Significantly higher CD4/CD8 ratio, IFN-γ concentration and IL12/IL4 ratio and significantly lower IL-4 concentration and proportion of shedders were found in HB than in other breeds. No other differences were found. In conclusion, this study did not provide evidence of peculiar immune profiles in HB, except for a prevalent Th1 profile, that may explain why in our caseload the rate of shedders was lower in HB than in other breeds.
Journal: Research in Veterinary Science - Volume 97, Issue 2, October 2014, Pages 263–270