کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2455055 | 1110504 | 2013 | 10 صفحه PDF | دانلود رایگان |
The impact of systemic inflammatory response syndrome (SIRS) on all phases of coagulation is largely unknown in dogs.Fifty-six healthy dogs (controls) and 25 diseased dogs were included. Based on physical and hematological examination, dogs were classified as “no-SIRS” (n = 7) or “SIRS” (n = 18). Evaluated coagulation variables included platelets, coagulation times, fibrinogen, antithrombin (AT), FVIII, protein C, protein S, activated protein C (APC)-ratio, calculated from aPTT with and without presence of APC, and kaolin-activated thrombelastography (TEG).Overall, no-SIRS and SIRS were characterized by hypocoaguable state (P < 0.001 compared to controls) i.e., prolonged coagulation times, decreased AT (median 59 U/L and 89 U/L versus 126 U/L), and FVIII (median 19 U/L and 70 U/L versus 102 U/L). In no-SIRS and SIRS, APC-ratio was significantly lower than in the controls (median 1.1 and 2.0 versus 2.5, P < 0.01, P < 0.001).Severe coagulopathies may be present in critically ill dogs without concurrent SIRS. APC-resistance is a frequent finding in severely diseased dogs.
Journal: Research in Veterinary Science - Volume 94, Issue 1, February 2013, Pages 122–131