کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2455317 1110510 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Detection of Mycobacterium tuberculosis infection in dogs in a high-risk setting
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Detection of Mycobacterium tuberculosis infection in dogs in a high-risk setting
چکیده انگلیسی

Dogs infected with Mycobacteriumtuberculosis can develop clinical tuberculosis (TB) but there are currently no validated immunological assays for diagnosing this infection in this species. Using a post mortem survey we investigated the prevalence of non-clinical M. tuberculosis infection and clinical TB disease in a high-risk population of dogs and developed and utilised a novel interferon-gamma release assay to determine the risk of transmission of M. tuberculosis from TB patients to contact dogs. The prevalence of clinical TB in dogs from a high-risk setting was 1% (95% CI: 0–5%) while the prevalence of immunological sensitization to M. tuberculosis antigens in dogs living in contact with sputum smear-positive TB patients was 50%. The IGRA proved a useful test of M. tuberculosis infection in dogs and the high levels of transmission of this pathogen from humans to companion dogs should be considered when assessing the zoonotic risks associated with such animals.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Veterinary Science - Volume 92, Issue 3, June 2012, Pages 414–419
نویسندگان
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