کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2455590 1110515 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunomodulation during and after castration under inhalation anaesthetic without genotoxic effects on equine lymphocytes
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Immunomodulation during and after castration under inhalation anaesthetic without genotoxic effects on equine lymphocytes
چکیده انگلیسی

Genotoxic DNA damage due to inhalation anaesthesia has been demonstrated in human lymphocytes. In order to evaluate anaesthesia-associated changes in cell-mediated immunity on the basis of a potential DNA damage as a health risk in horses, single cell gel electrophoresis and lymphocyte proliferation assay were performed on equine lymphocytes which were obtained before, during and after regular castration under inhalation anaesthetic. No significant lymphocytic DNA damage due to isoflurane anaesthesia was observed, whereas lymphocyte proliferative reactivity and lymphocyte counts decreased significantly (p ⩽ 0.05) during and after anaesthesia. The present study thus indicates that the combined anaesthesia does not result in significant DNA damage, which hence cannot be held responsible for the observed changes in the immune response of equine lymphocytes. However, the recognized compromises of immune function ought to be considered especially in immunologically challenged animals.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Veterinary Science - Volume 92, Issue 2, April 2012, Pages 306–310
نویسندگان
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