کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2455657 1110517 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MCT1, MCT4 and CD147 gene polymorphisms in healthy horses and horses with myopathy
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
MCT1, MCT4 and CD147 gene polymorphisms in healthy horses and horses with myopathy
چکیده انگلیسی

Polymorphisms in human lactate transporter proteins (monocarboxylate transporters; MCTs), especially the MCT1 isoform, can affect lactate transport activity and cause signs of exercise-induced myopathy. Muscles express MCT1, MCT4 and CD147, an ancillary protein, indispensable for the activity of MCT1 and MCT4. We sequenced the coding sequence (cDNA) of horse MCT4 for the first time and examined polymorphisms in the cDNA of MCT1, MCT4 and CD147 of 16 healthy horses. To study whether signs of myopathy are linked to the polymorphisms, biopsy samples were taken from 26 horses with exercise-induced recurrent myopathy. Two polymorphisms that cause a change in amino acid sequence were found in MCT1 (Val432Ile and Lys457Gln) and one in CD147 (Met125Val). All polymorphisms in MCT4 were silent. Mutations in MCT1 or CD147 in equine muscle were not associated with myopathy. In the future, a functional study design is needed to evaluate the physiological role of the polymorphisms found.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Veterinary Science - Volume 91, Issue 3, December 2011, Pages 473–477
نویسندگان
, , , , ,