کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2456481 1110543 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis
چکیده انگلیسی

We have performed a detailed investigation in 40 dogs naturally infected with Leishmania infantum (syn. chagasi), subdivided into three groups: asymptomatic (AD = 12), oligosymptomatic (OD = 12) and symptomatic (SD = 16), based on their clinical features. Twenty non-infected dogs (CD) were included as control group. Serological analysis, performed by IFAT and ELISA, demonstrated higher antibodies titers in SD in comparison to the AD. A positive correlation was found between parasite density in the spleen and skin smears as well as the bone marrow parasitism with clinical status of the infection. We observed that the progression of the disease from asymptomatic to symptomatic clinical form was accompanied by intense parasitism in the bone marrow. It is likely that this led to the impaired biochemical/hematological status observed. Finally, we believe that the follow-up of these parameters could be a relevant approach to be used as markers during therapeutic and vaccine evaluations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Veterinary Science - Volume 81, Issue 1, August 2006, Pages 68–75
نویسندگان
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