کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2456600 1110549 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A clinical study of plasminogen activator activity in gingival tissue in dogs with gingivitis and periodontitis
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
A clinical study of plasminogen activator activity in gingival tissue in dogs with gingivitis and periodontitis
چکیده انگلیسی

The aim of the present study was to evaluate plasminogen activator activity (PAA), tissue-type plasminogen activator (t-PA) antigen level and plasminogen activator inhibitor-1 (PAI-1) antigen in normal canine gingival tissue samples, gingivitis as well as in different stages of periodontal disease. Gingival tissue from 141 adult dogs were analysed spectrophotometrically in order to determine PAA. The tissues were also examined histopathologically. The Sulcus Bleeding Index was used to evaluate the active and inactive phase of periodontal disease. T-PA antigen as well as PAI-1 antigen level was measured by ELISA. There was a significant increase of PAA and t-PA antigen in samples from inflamed gingival tissue compared with normal gingival tissue, while PAI-1 antigen was not detected in either normal or inflamed gingiva. As the severity of periodontal disease was increasing, PAA and t-PA antigen values were significantly higher in periodontitis tissue sample groups, according to the pattern: gingivitis < early periodontitis < moderate periodontitis < severe periodontitis (P < 0.001). PAA and t-PA antigen were increased in samples from the inflamed gingival tissue with higher Bleeding Index, (heavy bleeding > moderate bleeding > slight bleeding, P < 0.001). In conclusion, this study indicates that PAA and t-PA antigen level may be used to evaluate the evolution of periodontal disease in dog.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Veterinary Science - Volume 80, Issue 2, April 2006, Pages 189–193
نویسندگان
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