Selenium supplementation: Confirmation of an effective 5-year delivery system for sheep

At the commencement of the study, whole blood Se and GSHPx activity levels were consistent with Se deficiency. The control animals remained in that state for the duration of the study. Sheep treated with HDP-P expressed an initial surge in blood Se and GSHPx values, which after 36 months declined to levels comparable with the control group. In contrast, sheep treated with the HDP-R exhibited a more consistent elevation in the blood parameters which persisted for the length of the trial. This study shows that the HDP technology can be formulated and manufactured to last for at least 5 years.