کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2463351 1555119 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relationship of body condition score and oxidant stress to tumor necrosis factor expression in dairy cattle
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Relationship of body condition score and oxidant stress to tumor necrosis factor expression in dairy cattle
چکیده انگلیسی

The relationship between body condition score (BCS) with measures of oxidative status and TNF-α production was examined in 16 mid-lactation dairy cows. Cows were selected based on either a normal (2.5–2.7) or a high (≥3.5) BCS using the standard five-point scaling system. The metabolic status of all cows was determined by plasma nonesterified fatty acid levels (NEFA). Plasma samples or white blood cell lysates also were analyzed for indices of oxidant stress and for the expression of TNF-α. Cows with a high BCS had significantly lower NEFA levels when compared to normal BCS cows and the over-conditioned animals were not in a state of negative energy balance. No significant changes in lipid hydroperoxide levels, glutathione peroxidase activity, or the ratio of reduced (GSH) to oxidized (GSSG) glutathione was detected with respect to BCS. However, high BCS cows did have a significantly lower overall antioxidant potential and reduced TrxR activities when compared with the normal BCS cows. Changes in the oxidative state of over-conditioned cows were accompanied by a significantly higher expression of TNF-α. Results from this study suggest that cows with a high BCS can experience oxidant stress in the absence of altered energy status. Increased TNF-α expression may be related to the pro-oxidant state of over-conditioned cows and possibly be a contributing factor to the enhanced susceptibility to disease in high BCS dairy cattle.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 113, Issues 3–4, 15 October 2006, Pages 297–304
نویسندگان
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