کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2465646 1111835 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel polymorphisms at codons 146 and 151 in the prion protein gene of Cyprus goats, and their association with natural scrapie
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Novel polymorphisms at codons 146 and 151 in the prion protein gene of Cyprus goats, and their association with natural scrapie
چکیده انگلیسی

To discern whether an association exists between specific combinations of polymorphisms of the prion protein (PrP) and natural scrapie in Cyprus goats, 250 goats were examined, including 164 histologically positive cases. Previously reported amino acid polymorphisms were detected at codons 154 (R → H), 168(P → Q), 220(Q → H) and 240 (S → P) and nucleotide alterations at codons 42 (a → g) and 138 (c → t). Additionally, novel amino acid polymorphisms were detected at codons 146 (N → S or D) and 151 (R → H) and new “silent” mutations were found at codons 179 (V, g → t), 181 (D, c → t) and 219 (T, c → t). The two novel polymorphisms at codon 146 were found only in the healthy control and scrapie-negative goats. By comparison, none of the scrapie-affected goats encoded these polymorphisms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Veterinary Journal - Volume 173, Issue 2, March 2007, Pages 459–462
نویسندگان
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