کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2473157 1555906 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hepatocarcinogenesis associated with hepatitis B, delta and C viruses
ترجمه فارسی عنوان
Hepatocarcinogenesis مرتبط با ویروس های هپاتیت B، دلتا و C
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
چکیده انگلیسی


• Hepatocellular carcinoma is one of the most prevalent and lethal forms of cancer.
• Infections with hepatitis B, C and delta viruses are main causes for HCC.
• Chronic liver inflammation and dysregulation of signaling pathways lead to malignant transformation.
• Better animal models are needed to study virally induced hepatocarcinogenesis.

Globally, over half a billion people are persistently infected with hepatitis B (HBV) and/or hepatitis C viruses. Chronic HBV and HCV infection frequently lead to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). Co-infections with hepatitis delta virus (HDV), a subviral satellite requiring HBV for its propagation, accelerates the progression of liver disease toward HCC. The mechanisms by which these viruses cause malignant transformation, culminating in HCC, remain incompletely understood, partially due to the lack of adequate experimental models for dissecting these complex disease processes in vivo.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Virology - Volume 20, October 2016, Pages 1–10
نویسندگان
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