Lipids and RNA virus replication

• Fatty acids provide additional phospholipids in the replicase factory.
• PI4P stimulates virus proteins and recruits effectors crucial for RNA replication.
• Cholesterol and sphingolipids help to organize a functional replicase factory.
• Virus assembly on LDs requires interaction between virus and LDs-bound proteins.

Most viruses rely heavily on their host machinery to successfully replicate their genome and produce new virus particles. Recently, the interaction of positive-strand RNA viruses with the lipid biosynthetic and transport machinery has been the subject of intense investigation. In this review, we will discuss the contribution of various host lipids and related proteins in RNA virus replication and maturation.

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