Type I interferons: diversity of sources, production pathways and effects on immune responses

Type I interferons (IFN-I) were first described over 50 years ago as factors produced by cells that interfere with virus replication and promote an antiviral state. Innate and adaptive immune responses to viruses are also greatly influenced by IFN-I. In this article we discuss the diversity of cellular sources of IFN-I and the pathways leading to IFN-I production during viral infections. Finally, we discuss the effects of IFN-I on cells of the immune system with emphasis on dendritic cells.

► A variety of cell types produce IFN-I during viral infections.
► Cells use multiple molecular pathways leading to IFN-I secretion.
► IFN-I impact the immune system, particularly DC.