کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2473771 | 1555944 | 2012 | 7 صفحه PDF | دانلود رایگان |
Protective antigens are targeted by host acquired immunity and able to induce protection against infectious diseases. To identify enriched features that do not typically exist in non-protective protein antigens, this study analyzed 201 protective protein antigens from Gram-negative bacteria and 69 protective protein antigens from Gram-positive bacteria available in the manually curated Protegen protective antigen database. Our study found that 64% of Gram+ protective antigens are extracellular or cell wall proteins and 48% of protective antigens in Gram-bacteria belong to extracellular or outer membrane proteins. Approximately 54% and 40% protective antigens in Gram+ and Gram-, respectively, are adhesins or adhesin-like proteins. Many conserved domains (motifs), such as Autotransporter and TonB domains, are enriched in protective antigens. A protection method based on SVM (Support Vector Machine) classification demonstrates 92% of true positive rate of sequence-based protection. This study represents a pioneer effort in the identification and prediction of specific patterns in protective antigens.
Journal: Procedia in Vaccinology - Volume 6, 2012, Pages 3-9