کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2473853 | 1113054 | 2009 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: New perspectives in vaccination and immunotherapies for HBV infections New perspectives in vaccination and immunotherapies for HBV infections](/preview/png/2473853.png)
The woodchuck hepatitis B virus (WHV), the closest genetically related virus of HBV, and its natural host Marmota monax constitute a well recognized animal model. The application of this model for the evaluation of immunogenicity and protection of new formulations of HBV vaccines for human use, for lamivudine-CHO-PreS/S vaccine therapy and WHV particles coupled with HBV derived woodchuck PreS/S antibodies (IC complex) studies, as shown that the PreS/S-CHO vaccine is the first human vaccine able to elicit non sterilizing protection in the woodchuck model. The very early appearance and selection of the domain B FLLA motif resistant mutant not neutralized by the antibodies produced following vaccination, has confirmed that more potent antivirals and/or multiple targeted options with possible inclusion of immune complexes should be considered.
Journal: Procedia in Vaccinology - Volume 1, Issue 1, 2009, Pages 35-40