کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2474429 1555972 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
T-cell epitope mapping for the design of powerful vaccines
ترجمه فارسی عنوان
نقشه برداری اپی توپ سلول T برای طراحی واکسن قدرتمند
کلمات کلیدی
نقشه برداری اپی توپ؛ واکسن؛ پاسخ همراه؛ ایمونولوژی مولکولی؛ سلول های T
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی و میکروب شناسی (عمومی)
چکیده انگلیسی

Epitope mapping has emerged as a powerful tool to design vaccines. It proved itself a number of times to reveal the building blocks of potent immuno-prophylactics. T-cell epitope mapping aims to identify the shortest amino acid sequence of an epitope of a specific antigen that is recognized by CD4+ and/or CD8+ T-cells. T-cell epitopes have the potential to stimulate both long lasting and exclusive cytotoxic immune response. Therefore, they are crucial for vaccine development against emerging intracellular pathogens such as Plasmodium malaria, Mycobacterium spp., genital Chlamydia, HIV, HCV as well as cancer cells. This review documents and discusses the different methods used in T-cell epitope mapping, and the role of each method to identify the potent epitopes in viruses, bacteria, parasites, as well as human diseases. The comment of the article guides the researchers to identify the most suitable mapping techniques for their antigens.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine Reports - Volume 6, December 2016, Pages 13–22
نویسندگان
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