کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2478948 1113413 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduced folate carrier 1 gene expression levels are correlated with methotrexate efficacy in Japanese patients with rheumatoid arthritis
ترجمه فارسی عنوان
سطح 1 بیان ژن حامل فولات کاهش یافته با کارآیی متوترکسات در بیماران ژاپنی مبتلا به آرتریت روماتوئید
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی

Responsiveness to methotrexate (MTX), the “anchor drug” for treating rheumatoid arthritis (RA), varies among individual patients. In this study we investigated the effects of folate transporter gene expression levels on disease activity among 56 Japanese patients with RA who were undergoing MTX therapy. We also assessed gene expression levels for 15 healthy control subjects. The mRNA expression levels of reduced folate carrier 1 (RFC1) and proton-coupled folate transporter (PCFT) in PBMCs from these patients and controls were determined using real-time quantitative polymerase chain reaction (PCR). Compared with PCFT, there were large individual differences in RFC1 mRNA expression levels in both RA patients and healthy controls. RFC1 mRNA expression levels and RA disease activity scores were significantly negatively correlated, as disease activity scores were lower for patients with higher RFC1 mRNA expression levels. However, RFC1 mRNA levels were not correlated with MTX doses. Thus, the clinical efficacy of MTX for Japanese RA patients was associated with the expression level of a folate transporter gene. Increased RFC1 expression may increase MTX uptake by immune cells, such as lymphocytes, and as a result, RA disease activity would be reduced.

Increased reduced folate carrier 1 expression may increase methotrexate uptake by immune cells, such as lymphocytes, and as a result, rheumatoid arthritis disease activity would be reduced.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Metabolism and Pharmacokinetics - Volume 30, Issue 3, June 2015, Pages 227–230
نویسندگان
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